Dialysate fluid flow in CVVHD: Does countercurrent flow increase clearance for small solutes?
نویسندگان
چکیده
منابع مشابه
Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes.
Clinical hemodialysis systems achieve high single pass extraction of small solutes that are not bound to plasma proteins. But they clear protein-bound solutes much less effectively. This study examines the extent to which clearance of a protein-bound test solute is improved by increasing the dialyzer mass transfer area coefficient (KoA) and the dialysate flow rate (Qd). A reservoir containing t...
متن کاملDialysate flow rate and delivered Kt/Vurea for dialyzers with enhanced dialysate flow distribution.
BACKGROUND AND OBJECTIVES Previous in vitro and clinical studies showed that the urea mass transfer-area coefficient (K(o)A) increased with increasing dialysate flow rate. This observation led to increased dialysate flow rates in an attempt to maximize the delivered dose of dialysis (Kt/V(urea)). Recently, we showed that urea K(o)A was independent of dialysate flow rate in the range 500 to 800 ...
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ژورنال
عنوان ژورنال: Australian Critical Care
سال: 2014
ISSN: 1036-7314
DOI: 10.1016/j.aucc.2013.10.014